Building developmental gene regulatory networks
نویسندگان
چکیده
منابع مشابه
Building developmental gene regulatory networks.
Animal development is an elaborate process programmed by genomic regulatory instructions. Regulatory genes encode transcription factors and signal molecules, and their expression is under the control of cis-regulatory modules that define the logic of transcriptional responses to the inputs of other regulatory genes. The functional linkages among regulatory genes constitute the gene regulatory n...
متن کاملProperties of developmental gene regulatory networks.
The modular components, or subcircuits, of developmental gene regulatory networks (GRNs) execute specific developmental functions, such as the specification of cell identity. We survey examples of such subcircuits and relate their structures to corresponding developmental functions. These relations transcend organisms and genes, as illustrated by the similar structures of the subcircuits contro...
متن کاملAssessing regulatory information in developmental gene regulatory networks.
Gene regulatory networks (GRNs) provide a transformation function between the static genomic sequence and the primary spatial specification processes operating development. The regulatory information encompassed in developmental GRNs thus goes far beyond the control of individual genes. We here address regulatory information at different levels of network organization, from single node to subci...
متن کاملModelling Developmental Regulatory Networks
This paper introduces a model for simulating regulatory networks that is capable of reproducing spatial and temporal expression patterns in developmental processes. The model is a generalization of the standard connectionist model used for modelling genetic interactions, where the terms for the regulation of gene products and the diffusion term have been separated. This model can be coupled wit...
متن کاملRobustness and Accuracy in Sea Urchin Developmental Gene Regulatory Networks
Developmental gene regulatory networks robustly control the timely activation of regulatory and differentiation genes. The structure of these networks underlies their capacity to buffer intrinsic and extrinsic noise and maintain embryonic morphology. Here I illustrate how the use of specific architectures by the sea urchin developmental regulatory networks enables the robust control of cell fat...
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ژورنال
عنوان ژورنال: Birth Defects Research Part C: Embryo Today: Reviews
سال: 2009
ISSN: 1542-975X,1542-9768
DOI: 10.1002/bdrc.20152